Alcoholism – NCSAPCB Wed, 29 Jun 2022 11:14:53 +0000 en-US hourly 1 Alcoholism – NCSAPCB 32 32 Mark Appel reaches MLB 9 years after first pick Mon, 27 Jun 2022 15:12:46 +0000

Mark Appel, drafted No. 1 by the Astros in 2013, won his first MLB call Saturday with the Phillies.

Why is this important: Appel, 30, was one of only three The No. 1 in MLB history chooses to sign with his team but never makes it to the big leagues. He is now off this list after coming to “the show”.

  • “Completely overwhelmed” said Call. “I have so many thoughts that I want to share but I can’t find the words, so I’m just going to say this: I’m grateful.”
  • The context: Nine years is one long duration. Other 2013 recruits like Kris Bryant (#2), Tim Anderson (#17), Aaron Judge (#32) and Cody Bellinger (#124) have already become superstars.

The backdrop: The Stanford graduate and 2012 National Pitcher of the Year was drafted first overall in 2013 by his hometown Astros, who signed him for $6.35 million.

  • He was MLB’s No. 6 pitching prospect in 2014 before Houston traded the often injured and ineffective Appel to the Phillies in 2015.
  • In 2018, struggling with inconsistencies, hurts and the Depression, he quit baseball. Three years later, he returned to the Phillies organization, where he excelled as a reliever that season in Triple-A.
  • On Saturday, with reliever Connor Brogdon on COVID IL, he finally got the call he’s been waiting for for nearly a decade.

The big picture: Appel was an established college star before injuries derailed his professional career, but two high school recruits who endured similarly long delays offer optimism for his future.

  • Matt Bush, the No. 1 pick in 2004, made its debut in 2016 after battling alcoholism. At 36, he is still part of the Rangers bullpen.
  • Josh Hamilton, the first pick in 1999, made his debut in 2007 after battling alcoholism and drug addiction. He won the 2010 AL MVP and was a five-time All-Star.

The bottom line: No matter how talented you are, it’s impossible to prove yourself if you never get the chance. Mark Appel finally gets his.

Barbara Bach: Bond girl beat alcoholism with Ringo Starr – “We used to be bothered” Sat, 25 Jun 2022 18:00:00 +0000

As well as being famous for playing Anya Amasova in Tonight’s Bond movie, she’s also known for her rocky marriage to Beatles drummer Ringo Starr – who she’s been in a relationship with since 1981. In the foreword of a 1992 book by Derek Taylor—the band’s publicist—called Getting Sober, Starr described their relationship as riddled with alcoholism.

Starr, who met Bach in 1980 on the set of Caveman, wrote: “We used to take long plane trips, rent huge villas, fill bars, hide and upset.

“I came on a Friday afternoon and the staff told me that I had trashed the house so much that they thought there had been burglars, and I had trashed Barbara so much that they thought that she was dead.”

At the time of their alcoholic lovemaking, their two children took refuge in boarding school. Her daughter Francesca Gregorini even declared in 1989 that she had become a “better academic”. “It was the height of their drugs…I was always hiding in a room reading because mom and dad were out,” Gregorini said.

After years of precarious events, including blackouts and violence, the couple had had enough of their habits and decided to start trying to quit in 1998.

READ MORE: Clint Eastwood’s health: The anti-anxiety trick the star has been using for ‘over 40 years’

Alcoholism is rampant among the UK population – out of 602,391 people they are predicted to be addicted to the drink, according to Alcohol Change UK.

For many people, including celebrities like Starr and Bach, this habit is difficult to break and may require the support of organizations.

Ringo Starr and Barbara Bach sought help at a rehabilitation clinic in Tuscan, Arizona. Since their treatment, the couple have stayed sober.


At the rehab in Arizona, they shared a room and were treated together.

In the UK, support for alcoholism is also available. Through the NHS, you can benefit from a ‘brief intervention’ session.

The health body says: “If you are worried about your drinking or have had an alcohol-related accident or injury, you may be offered a brief tips brief intervention session.

Addicts may also choose to attend self-help groups, such as Alcoholics Anonymous, for additional counseling or cognitive behavioral therapy (talking therapy).

READ MORE: Hair loss: Scientists find link between hair growth and crucial body part

Some people may even decide to quit alcohol altogether.

As the NHS puts it, “the choice is yours”, but it may be wise if you have severe liver damage or other health conditions.

Conditions such as heart disease, for example, can be made worse by drinking alcohol.

AEW’s Jon Moxley Opens Up About Alcoholism: ‘I Was In Living Hell’ | Launderer’s report Fri, 24 Jun 2022 16:19:48 +0000

Frank Jansky/Icon Sportswire via Getty Images

Ahead of his match against New Japan Pro-Wrestling legend Hiroshi Tanahashi for the Interim AEW World Championship at Forbidden Door on Sunday, AEW star Jon Moxley opened up about his alcohol addiction and his recovery in progress.

In an interview with ESPN Marc Raimondi this week, Moxley discussed what led him to enter an inpatient alcohol treatment program on Halloween night last year.

Moxley told Raimondi that he had been addicted to alcohol for a long time and was “screwed for almost 18 years”.

He said he basically needed alcohol to function on a daily basis and was afraid to quit after googling alcohol withdrawal symptoms, which included seizures, cardiac arrest and even death.

As a result, the former WWE and AEW World Champion had embarked on a destructive routine of waking up hungover before drinking water, using the sauna and taking aspirin throughout the day.

When he could barely function after getting drunk before a flight home to his wife and three-month-old daughter, and couldn’t take his daughter for Halloween tricks or treats, Moxley decided it was time to get help.

After a successful stint in the treatment program, Moxley returned to AEW about three months later in January and appeared to be in spectacular physical condition compared to before.

Moxley said that although he faced challenges during his recovery, such as nightmares and mood swings, it was a major improvement, saying, “I’m going to take this route from this. that I was going through before, especially in the last few months. [before treatment]. I do not know. Everything blurs together. I was in living hell, absolute hell.”

Renée PaquetteMoxley’s wife and former WWE host, said Thursday that Moxley has been sober since undergoing treatment nearly eight months ago.

Even before getting help, Moxley was considered one of the best wrestlers in the world, enjoying success in AEW, WWE, and several other promotions around the world.

Since returning to wrestling in January, he’s cemented himself as one of AEW’s biggest and most popular stars, earning himself a prime spot in a landmark pay-per-view.

On Sunday, Moxley will take part in one of the biggest matches of his career, the Main Event of a co-scored event hosted by AEW and NJPW.

If Moxley defeats Tanahashi, it will set the stage for a future AEW World Championship match between Moxley and CM Punk, which is among the most anticipated wrestling matches.

Mycobacterium abscessus pneumonia in severe alcoholism Thu, 23 Jun 2022 17:23:20 +0000

In the USA, Mycobacterial tuberculosis the infection is not common and the infection rate has decreased significantly (incidence of 2.4 cases per 100,000 people in 2021 compared to 12.2 in 1980 according to the CDC website). The incidence of nontuberculous mycobacterial infections (NTMs) is increasing rapidly. A relatively recent study suggested an increase in incidence from 2.5 cases per 100,000 people in the 1980s to 15.2 cases per 100,000 people by 2013 in the United States. [1]. Nontuberculous mycobacterial lung disease is typically described in patients with underlying parenchymal lung disease such as cystic fibrosis, bronchiectasis, or a history of tuberculosis, as well as in immunocompromised patients, such as those with Advanced HIV or other forms of long-term immunosuppression. [2]. This report describes the unique case of a 52-year-old man who was diagnosed with Mycobacterium abscessus lung disease with chronic alcohol dependence disorder as the only significant risk factor in his medical history. The medical literature has suggested that alcoholism is a risk factor for NTM lung infections and with this case report we highlight the importance of understanding this association. [3].

A 52-year-old man with a medical history of alcohol dependence disorder and anxiety presented to the emergency department with nonspecific pain in his left upper back for three to four months. The pain was in the left side of the upper back and above the shoulder blade, gradually getting worse and radiating to the left armpit and upper left chest. He described the pain as acute, intermittent and without aggravating factors. The patient also approved of involuntary weight loss, approximately 11 pounds over the past two to three months. Besides weight loss, he had no B-cell symptoms such as fever, night sweats, changes in appetite or fatigue.

The patient had no history of incarceration or homelessness. The only travel story for him was a cruise to the Caribbean islands for a short time. He had mostly lived in Florida and Tennessee when he was young and was now domiciled in New York. He has a history of alcohol dependence disorder (eight to 10 cans of beer a day) but no history of recreational drug use or smoking. He denies any history of recurrent infections, any sick contact or contact with patients infected with tuberculosis. He had no history of vaccination against bacille Calmette-Guérin (BCG) nor any history of opportunistic infections in the past. When he arrived in the ER he was tachycardic and tachypneic but otherwise hemodynamically stable (temp 98.1 Fahrenheit, blood pressure 110/55 mmHg, heart rate 140, respiratory rate 32 with SpO2 74% on room air). The examination was relevant for a decrease in breath sound on the left lung fields and tachycardia. He was then placed on oxygen supplementation by high-flow nasal cannula with an improvement in his SpO2 to 94%.

He underwent an emergency chest computed tomography with intravenous contrast which revealed a 6.8 x 5.1 x 6.7 cm irregular cavitary lesion in the left hilum and left upper lobe with a 1.5 cm nodular component along the along the posterior side; severe narrowing of the left main pulmonary artery with attenuation of the branch of the left upper lobe segment; additional smaller thick-walled cavities noted in the lingula measuring up to 2.7 x 1.6 x 1.3 cm; and multiple centrilobular and arborescent nodules in the right middle lobe, lingula, and left lower lobe (Figure 13). He was admitted for a complementary infectious assessment.

In the assessment carried out, he had a purified protein derivative (PPD) done which was negative, QuantiFERON was indeterminate and the HIV screening was negative. He eventually underwent bronchoscopy and bronchial alveolar lavage was sent for cultures which tested positive for Mycobacterium abscessus (Table 1). The patient was eventually initiated on an intravenous antibiotic regimen with amikacin, tigecycline, and cefoxitin via a peripherally inserted central catheter (PICC) line based on the results of susceptibility testing, which is planned to be continue for at least six to 12 months. He will be followed closely in the outpatient department to determine clinical improvement and resolution of the cavitary lesion with serial clinical imaging.

Amikacin 16 μg/ml (susceptible)
Cefoxitin 64 μg/ml (intermediate)
Ciprofloxacin >4 μg/ml (resistant)
Clarithromycin >16 μg/ml (resistant)
Doxycycline >16 μg/ml (resistant)
Imipenem >32 μg/ml (resistant)
Linezolid >32 μg/ml (resistant)
Moxifloxacin >8 μg/ml (resistant)
tigecycline 0.25 μg/ml (No interpretation available)
Tobramycin 16 μg/ml (resistant)
Trimethoprim-sulfamethoxazole 8 μg/ml (resistant)

Nontuberculous mycobacteria (NTM) have been recognized for many years as pathogenic organisms. Although they are regularly present in the environment of body surfaces or secretions as colonizers, the rate of clinical infection in humans is considered to be low. Since reporting is not mandatory in several countries around the world, the exact frequency of illness due to different NTM species is not determined. An estimated prevalence of disease in the United States was approximately 15.2 cases/100,000 in 2013. It should also be noted that isolation of NTM does not necessarily indicate infection. [1,4].

NTM infections are usually seen in immunocompromised patients, such as those with a history of tuberculosis infection, advanced HIV disease, cystic fibrosis, and a history of taking immunosuppressive drugs. Diseases caused by NCDs are classified into major clinical syndromes: lymph node disease (lymphadenitis), skin disease, musculoskeletal disease, lung disease and disseminated disease according to organ system involvement. There are over 170 identified species, however, the Mycobacterium avium complex, Mycobacterium kansasii, Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum are the most reported in infections [5,6].

Previously thought to be rare, NTM infections are now increasingly recognized, especially with the advancement of detection techniques such as the polymerase chain reaction. Lung involvement is considered the most common manifestation of the infection. Predisposing factors are basic parenchymal lung diseases such as bronchiectasis, chronic obstructive pulmonary disease, interstitial lung disease or immunosuppression in uncontrolled HIV infection, after transplantation and use anti-tumor necrosis factor-α biologics. [7]

Some studies have shown that lung NTM infections are noted in postmenopausal female populations without immune dysfunction but with a slender physique, scoliosis, and mitral valve prolapse. Other less common risk factors described in the literature include gastroesophageal reflux disease, vitamin D deficiency, low body mass index, and rheumatoid arthritis. [8]

We describe an interesting case of lung disease Mycobacterium abscessus in a patient with severe alcohol dependence disorder but an otherwise immunocompetent individual. It was not noted that he had a significant history of predisposition to lung parenchymal disease at baseline, and no history of systemic immunosuppression was noted. Theoretically, we suggest that a history of alcohol dependence disorder, although not properly understood, may have played some role in predisposing to NTM infection. Alcohol consumption has been suggested to have an altering effect on innate and adaptive immune responses and dysregulation of the inflammatory cascade predisposing to viral and bacterial infections and sterile inflammation [9]. Additionally, alcohol dependence is also associated with gastroesophageal reflux. [10]. We hypothesize that alcohol-induced reflux disease may have played some role in our patient’s predisposition to have NTM lung infection. The association of gastroesophageal reflux disease with NTMs has not been studied in detail, but limited data suggest a high prevalence of such infections even in the absence of classic reflux disease symptoms. [11].

infections by Mycobacterium abscessus are conventionally considered difficult to manage without standard treatment. Treatment options are limited with current antimicrobial agents and are therefore often considered an incurable chronic infection in the right clinical setting. [12]

Nontuberculous mycobacterium is an important environmental pathogen that can cause a wide range of diseases in humans. It is important to elucidate important risk factors, including dysregulation of the immune system that may predispose to significant infections by these organisms. Alcoholism is considered an important risk factor for predisposing patients to NTM infections and with this case report we urge more robust studies to assess this association.

New blood biomarker identified for the status of Tue, 21 Jun 2022 18:17:16 +0000

A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease. As part of the immune system, these cells have a protective function against liver fibrosis and cirrhosis. At the same time, they are useful as biomarkers of liver disease progression because they can be measured by a blood test. The results were recently published in the famous “Journal of Hepatology“.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide and is estimated to affect approximately 30% of the European population. Chronic non-alcoholic fatty liver disease can progress to irreversible cirrhosis of the liver, which can only be cured by liver transplantation. Therefore, early identification of patients with non-alcoholic fatty liver disease is particularly important.

The pathogenesis (development) of non-alcoholic fatty liver disease, in particular advanced steatohepatitis (NASH, also: non-alcoholic fatty hepatic hepatitis), is associated with profound changes in the immune cells of the liver. Recently, increased accumulation of a subtype of macrophages that express high levels of the TREM2 receptor has been described in fatty liver disease.

However, the role of TREM2 positive macrophages in non-alcoholic fatty liver disease was so far unknown. The MedUni Vienna research team led by Christoph Binder and Tim Hendrikx from the Department of Laboratory Medicine was able to show in an animal model that these specific macrophages have a protective function in fibrosis – a precursor to cirrhosis of the liver. These cells are found in greatest numbers in affected areas of the liver during liver inflammation associated with non-alcoholic fatty liver disease, where they particularly accumulate in areas of cell damage and fibrosis.

The interdisciplinary study team also demonstrated in bone marrow transplant models that hematopoietic TREM2 deficiency prevents efficient fat storage and the breakdown of excess connective tissue (extracellular matrix), resulting in increased steatohepatitis, cell death and fibrosis. Therefore, TREM2-positive macrophages perform an important protective function in non-alcoholic fatty liver disease, where they prevent fat accumulation, inflammatory processes and disease progression to liver fibrosis. “It might be possible to develop new therapeutic approaches to treat fatty liver disease by enhancing this protective function of TREM2-positive macrophages,” said Florentina Porsch, co-first author of the study.

Excellent biomarker
TREM2 exists both as a membrane receptor on cells and as a soluble form (sTREM2) detectable in blood. The role of this soluble form in the immune system is not yet clear. However, the study authors found that it is useful in patients to determine current disease status and helps distinguish between different stages of fatty liver disease much better than previously known biomarkers used in clinical practice. . “The soluble form of TREM2 is an excellent biomarker for identifying and staging advanced liver disease, which can progress from fatty liver disease to incurable cirrhosis if left untreated,” says first author Tim Hendrikx from the Department of Medicine. laboratory of MedUni Vienna.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Songwriter Paul Williams lost a decade to alcoholism Sun, 19 Jun 2022 14:00:00 +0000

Singer and songwriter Paul Williams says he “lost” the 80s due to his alcoholism at the time.

“I drank, I used, like most people do for about seven minutes, and then by the time I got sober, I had lost a decade,” he exclusively told Page. Six at the Songwriters Hall of Fame’s annual induction and awards gala on Thursday night. .

“The 80s were over for me,” added the 81-year-old. “I was incredibly productive and lucky and lucky, lucky, lucky in the 70s. In the 80s, I stayed home and alphabetized my canned goods.

Williams – who received the prestigious Johnny Mercer Award at the gala – was certainly “incredibly productive” in the 70s, co-writing “Evergreen”, from “A Star is Born” with Barbra Streisand in 1991 (collecting an Emmy and Grammy in the process), and co-wrote “Rainbow Connection”, sung by Kermit the Frog, in 1979.

Other songwriting credits include “We’ve Only Just Begun” by The Carpenter, “An Old Fashioned Love Song” by Three Dog Night, and theme lyrics for “The Love Boat”.

He was also an on-screen mainstay, appearing in all three “Smokey and the Bandit” films and making guest appearances on shows like “The Odd Couple” and “Fantasy Island.” The composer was also a regular guest on “The Tonight Show”.

Paul Williams and Kermit the Frog.
Williams co-wrote “The Rainbow Connection” for “The Muppet Movie.”
The puppet show

It wasn’t until the age of 49 that Williams recognized his illness.

“I turned to people and asked for help,” he shared. “I said, ‘I’m lost and I need help,’ and the recovery community came out of nowhere to help me and I loved it. I didn’t just chase music after that i went to UCLA and got certified as a drug and alcohol counselor i found my tribe and what happened is i started writing songs again .

Actress/singer Barbra Streisand and songwriter Paul Williams attend the 34th Annual Golden Globe Awards on January 29, 1977 at the Beverly Hilton Hotel in Beverly Hills, California.
Williams and Barbra Streisand won an Oscar for writing “Evergreen.”
Ron Galella Collection via Getty

Most recently, the Grammy winner penned two songs for Daft Punk’s 2013 album, “Random Access Memories.”

Williams added coyly that he never really had a “moment of clarity” regarding his alcoholism.

Pictured: (lr) singer Steve Lawrence and songwriter Paul Williams during an interview with host Johnny Carson on July 22, 1977.
Williams was a regular guest on “The Tonight Show.”
NBCU Photo Bank/NBCUniversal via

“During a blackout, I called a doctor and told him I wanted to get sober,” he explained. “The week before I had been to Oklahoma for a concert and had a complete psychotic breakdown because I was so loaded.

“I found out 10 years later that the guy who had been promoting the concert was long sober and he set up a prayer circle to pray for me to find relief from my addiction. A week later, during a blackout, I called a doctor.

Gallstone disease, benefits of owning a dog, alcoholic hepatitis Sat, 18 Jun 2022 12:03:06 +0000 Subscribe We have not been able to process your request. Please try again later. If you continue to have this problem, please …]]>

We have not been able to process your request. Please try again later. If you continue to have this problem, please contact

Here are Healio’s top 10 peer-reviewed articles from Digestive Disease Week 2022, which highlight research on restrictive diets, gallstone disease, dog ownership and Crohn’s disease, the response of COVID-19 antibodies and more.

Restrictive diets offer greater symptom reduction compared to medical treatment in patients with IBS

Two restrictive diets were superior in reducing symptoms compared to optimized medical treatment alone in patients with irritable bowel syndrome.

“There are several different treatment options that are effective in relieving IBS symptoms, and dietary treatment may indeed be encouraged as a first-line treatment option,” Sana NybackaRD, PhD, from the Department of Molecular and Clinical Medicine at the University of Gothenburg in Sweden, Healio told. “Our findings support current IBS treatment guidelines, where a positive IBS diagnosis is crucial for successful management of IBS and should be followed by general lifestyle intervention and dietary advice. Medical treatment should be guided by the patient’s symptom profile and preferences as a second-line treatment option.

Cholelithiasis may be predictive of pancreatic cancer

Patients with pancreatic ductal adenocarcinoma were six times more likely to have had cholelithiasis or cholecystitis in the year before diagnosis compared to the general population.

“Pancreatic cancer is often fatal, as it is often only diagnosed at an advanced stage. What complicates the initial diagnosis is that early symptoms often mirror those associated with gallstone disease and gallbladder inflammation, both of which have been shown to be risk factors for pancreatic cancer.” , Teviah E.Sachs, MD, MPH, associate professor and chief of surgical oncology at Boston Medical Center, said at the DDW press conference. “Unfortunately, little is known about how often these conditions occur before the diagnosis of pancreatic cancer.” Read more.

Early dog ​​ownership may protect against developing Crohn’s disease

Ownership of a dog and close interactions with these pets in early childhood could help prevent the later development of Crohn’s disease.

“Our study appears to add to others that have explored the ‘hygiene hypothesis’ which suggests that lack of exposure to microbes early in life may lead to a lack of immune regulation towards environmental microbes” , Williams Turpin, Ph.D., research associate at Mount Sinai Hospital and the University of Toronto, said in a news release. Read more.

Unrecognized alcoholic hepatitis linked to higher mortality, hospitalization

A significant proportion of alcoholic hepatitis cases remain unrecognized and are correlated with higher 30-day mortality, length of hospital stay, and ICU admission.

“It remains to be determined whether this increased mortality is due to untreated versus the decreased tendency in this group to seek medical attention (presence of other comorbidities),” Julton Tomanguillo Chumbedoctor, from the division of gastroenterology at Charleston Area Medical Center in West Virginia, and colleagues wrote. Read more.

Rectal expulsion device may predict outcome in patients with chronic constipation

An experimental point-of-care rectal expulsion device may help determine whether patients with chronic constipation will improve with pelvic floor physical therapy.

“The Rectal Expulsion Device was specifically designed to simplify and pull the tertiary care paradigm of anorectal function testing downstream to the medical office of any general gastroenterologist for patients with chronic constipation,” Eric D. Shah, MD, MBA, assistant professor at Dartmouth College Geisel School of Medicine and Dartmouth-Hitchcock Medical Center in New Hampshire, Healio told. Read more.

Antibiotic use linked to increased risk of older-onset IBD

Antibiotic use, particularly those targeting gastrointestinal pathogens, was associated with an increased risk of older-onset inflammatory bowel disease.

“This risk is higher with each subsequent antibiotic treatment prescribed, within 1-2 years of antibiotic use, and with antibiotics targeting gastrointestinal pathogens,” Adam S. Faye, MD, MS, assistant professor of medicine and population health at NYU Grossman School of Medicine, Healio told. Read more.

Biologics linked to lower rate of dementia in older patients with IBD

Older patients with IBD who were treated with biologics had a lower incidence of dementia than those who were never treated with biologics.

“When we looked at a national database, we found an increased rate of dementia in patients with IBD,” Ahmad Eltelbanydoctor, an internist at the Cleveland Clinic, told Healio. “However, when we further stratified our study to examine the use of biologics among these groups of patients, we found that the group that used biologics had a reduced prevalence of dementia compared to the group that did not receive biologics. Organic Products.” Read more.

Debate: “Safety, suitability, cost” still favor percutaneous ultrasound biopsy over endoscopic biopsy

Although percutaneous liver biopsy is still the “gold standard”, technical advances and the increased use of ultrasound-guided endoscopic biopsy may soon change this dynamic.

“Endoscopic ultrasound-guided liver biopsy has several advantages, not the least of which is patient comfort.” David L. Diehl, MD, FASGE, from Geisinger Medical Center in Danville, Pa., told attendees. “It provides exceptional sampling yields with current techniques, and it is possible to do bi-lobar sampling in a very simple way, which can reduce sampling error.” Read more.

Cannabinoid use increases the need for higher sedation during endoscopy

Baseline cannabinoid use associated with the need for increased sedation in patients who underwent endoscopy with conscious sedation directed by an endoscopist.

“Endoscopist-directed conscious sedation, or EDCS, is widely used for routine endoscopic procedures such as gastroscopy and colonoscopy. Although effective and cost-effective, EDCS can be limited by the inability to achieve sufficient levels of sedation”, Yasmin Nasser, MD, PhD, assistant professor of medicine at the University of Calgary, said. “With the legalization [of cannabis] over the past decade there has been increasing use. …Given the underlying properties of cannabinoids and their potential for interactions with opiates and benzodiazepines frequently used in EDCS, it is biologically plausible that baseline cannabinoid use may influence sedation requirements for endoscopy. Read more.

Additional doses of SARS-CoV-2 vaccine increase antibody response in patients with IBD

Seroconversion rates and antibody response increased significantly after a third dose of SARS-CoV-2 vaccine in patients with IBD.

“Responses to the third and fourth doses were significantly stronger than a two-dose regimen,” Joshua Quan, MSc, a master’s student at the University of Calgary’s Cumming School of Medicine, told attendees. “Furthermore, the antibody responses deteriorated over time from the second to the third dose of vaccination, which really highlights the need for a third dose of vaccination.” Read more.

]]> Hunter Biden’s ex-wife Kathleen Buhle details years of alcoholism, drug addiction and infidelity in new memoir If We Break Tue, 14 Jun 2022 12:15:11 +0000

In his new memoirs If we break, Kathleen Bühle doesn’t shy away from the ugly side of his 24-year marriage to Biden hunter and the ramifications it had on his own mental health and that of their three daughters, Noemie, finneganand Maisy.

In the book, Buhle shares that she started noticing Hunter’s drinking might be a problem around 2001 after the birth of their second child when he took a job as a partner at a lobbying firm. in Washington, DC, which led to a lot of late nights. and long periods away from their home in Delaware. “I saw his drinking spiral go from social to problematic,” she wrote. “Seeing how much he could consume scared me… For the first time, I didn’t trust my husband.” In the fall of 2003, Hunter entered rehab for the first time, and upon his return, the author said their marriage “felt stronger than ever.” But after seven years of sobriety, Hunter again relapsed into denial, forcing Buhle into the permanent role of sobriety detective. “As my suspicions grew, so did Hunter’s defense,” she says. “He made me think I must be crazy, when what I wanted from him was honesty. But I didn’t know how to ask for it.

When Hunter returned home after finally agreeing to a second stint in rehab in 2012, Buhle says she tried to “reignite our marriage…We weren’t fighting, not at first. We just seemed to drift apart. From the outside, everything was as it should be… But inside, at home, we weren’t sharing. And in the spring of 2013, she started noticing the warning signs that he was drinking again.” I didn’t trust my husband, and he didn’t trust me either, as if my own suspicions of him made me suspect… Sometimes I even believed that it was my own skepticism of him that was the problem,” she wrote, blaming herself for driving her husband even further into his addiction.

After Beau Biden is diagnosed with a deadly form of brain cancer, Buhle once again watches her husband’s drinking become “worse than ever”, finding beer cans and vodka bottles strewn about their home. She begins to lose faith that he will ever be able to stop. “Each time he drank, the process of getting him to admit he wasn’t sober took longer and was more exhausting,” she says. “The denials got angrier and more bitter too. For the first time, Hunter insulted me. And as Beau’s illness worsened, Buhle writes, “Hunter’s drinking was evident in the darkest and most angry way.”

After more than a decade of battling her husband’s alcoholism, Buhle admits the reality that Hunter might also use drugs had never even occurred to her. That was until he confessed in late 2013 that earlier that summer he had failed a drug test needed to join the Navy, testing positive for cocaine – a drug he completely denies having taken. Years later, after Beau’s death, Buhle would also discover evidence that Hunter smoked crack, found a broken glass pipe in an ashtray at their home after a night of drinking, and later discovered a pipe and a small bag full of it. of a white substance. hidden in their car. But by then Buhle writes, “After years of thinking it couldn’t get any worse, I had lost the ability to be surprised by him.”

As if coping with Hunter’s alcoholism and drug addiction wasn’t enough of a challenge for their relationship to endure, Buhle also uncovers evidence of his infidelity years before he gets caught cheating on her with it. his late brother’s wife, Hallie. After Buhle finds photos on his iPad of a woman in a dressing gown in her Paris hotel room, Hunter eventually admits he cheated on her five times during their marriage, claiming that they were “all prostitutes. All out of the country,” and only when he was drinking. Buhle admits that not only did her entanglement with her husband keep her from leaving him, but she was also told by Hallie that if she left him, she would only regret it as Hunter would surely move on to someone else. Buhle’s therapist also told him at the time that “he didn’t think Hunter would be able to handle the loss of Beau and me at the same time.” So she decides to stay. But just as the author finally begins to forgive her for her past indiscretions, Hunter begins to distance herself from her again, spending more and more time with Hallie and her children after Beau passes away. She notices that Hallie is also starting to treat her more coldly. After years of friendship and family vacations, Buhle writes, “For the first time she seemed really tired of me. Soon, she would stop answering me at all. One of my last texts told him that I didn’t understand what was going on and that I felt like I was being punished. I did not have any answer.

India exported alcoholic products worth $322.12 million in 2020-2021 Fri, 10 Jun 2022 12:37:00 +0000

India exported 2.47 lakh metric tons of alcoholic products, worth $322.12 million (about Rs 2,507 crore), in 2020-2021, the Ministry of Commerce said on Friday.

The main export destinations for Indian alcoholic products are the United Arab Emirates, Ghana, Singapore, Congo and Cameroon.

He said the demand for Indian products such as malt-based beer, wine, white wine, brandy, whiskey, rum and gin has increased significantly in the global market.

The Agricultural and Processed Food Products Export Development Authority (APEDA) has organized several workshops and wine tastings at various international trade fairs to raise awareness of the potential of local wines.

India’s wine industry grew at a compound annual growth rate of 14% between 2010 and 2017, making it the fastest growing alcoholic beverage industry in the country, he added.

In a bid to boost the export of wines, APEDA facilitated the participation of ten exporters in the London Wine Fair, 2022.

(Only the title and image of this report may have been edited by Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)

Dear reader,

Business Standard has always endeavored to provide up-to-date information and commentary on developments that matter to you and that have wider political and economic implications for the country and the world. Your constant encouragement and feedback on how to improve our offering has only strengthened our resolve and commitment to these ideals. Even in these challenging times stemming from Covid-19, we remain committed to keeping you informed and updated with credible news, authoritative opinions and incisive commentary on relevant topical issues.
However, we have a request.

As we battle the economic impact of the pandemic, we need your support even more so that we can continue to bring you more great content. Our subscription model has received an encouraging response from many of you who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of bringing you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practice the journalism we are committed to.

Support quality journalism and subscribe to Business Standard.

digital editor

Digging Deep: Teenage Alcoholism and Its Effects on the Adult Brain Fri, 10 Jun 2022 10:15:23 +0000 A recent study linked adolescent alcoholism to brain disorders later in adult life. Bohnsack et al. (2022), reporting in Science this month, claim that heavy drinking in adolescence impacts the amygdala, which is part of the brain’s temporal lobe involved in managing memory and emotions .

By conducting experiments on mice and supplementing information from humans, scientists found that drinking alcohol between the ages of 18 and 25 led to a reduction in the production of activity-regulated cytoskeletal protein (ARC)which plays a key role in creating and consolidating memories.

This is done via an “epigenetic” deletion of synaptic activity response element (SARE), a region of DNA close to the genetic code responsible for the production of ARC. Epigenetic phenomena are those where the environment in which an individual grows and lives, as well as his behavior, affects the behavior of genes.

There is, however, no change in the actual DNA sequence, but in the structure of chromatin – a complex of DNA and proteins – which packs DNA tightly inside the nucleus. In particular, chromatin contains many nucleosomes, which are DNA wrapped around 8 histone proteins, like a thread around a bobbin. But is there a clear link between alcohol consumption and changes in the histone protein that suppress the production of the ARC protein?

The best of Express Premium
“Hoping for more direct taxes than expected for this fiscal year;  watch her cry...Prime
Married and without prejudicePrime
The picture of Rajiv Gandhi getting hit - the story in a framePrime

In order to establish a relationship between the environment/behaviour and the SARE site, Bohnsack et al. 2022 used CRISPR-dCas9, a tool used for epigenetic modifications, to modify histone proteins. The dCas9 protein was attached to P300, a histone protein that promotes RNA production (the RNA is then converted into protein), and targeted to the SARE site. Next, the SARE site was targeted by dCas9 attached to KRAB, a protein that suppresses RNA copying.

“These new and rapidly evolving tools make it possible to selectively modify the epigenome at a single genomic locus and to study downstream effects at the molecular, cellular, circuitry and behavioral levels,” say the study authors. These experiments were conducted on a group of mice with unlimited access to food and water; and the target tissue region was the central core of the amygdala.

The study revealed that when the site is targeted by the dCas9-P300 complex, the expression of ARC increases. When the site is targeted by the dCas9-KRAB complex, the expression of ARC decreases. Therefore, one thing is clear, that epigenetic remodeling of SARE alone is able to flip ARC expression in both directions.

Bohnsack et al. (2022) also demonstrate that not only rodents that consume alcohol in adolescence exhibit anxiety-like behaviors, but also increased alcohol consumption in adulthood. SARE epigenetic mutations capable of recovering lost ARC expression (due to alcohol consumption) resulted in decreased alcohol dependence as well as decreased anxiety behaviors in adulthood. SARE mutations that further reduced ARC expression (here, dCas9-KRAB) only served to exacerbate alcohol dependence and anxiety in adulthood. This result, according to the authors, establishes a strong link between alcohol consumption in adolescence and its consequence on the ARC gene.

The research also describes the mechanism by which epigenetic remodeling of SARE regulates the expression of a gene that is nearly 7000 base pairs long (base pair is the unit by which the length of a DNA sequence or RNA is measured) away from it. This mechanism is known as “chromatin looping”. Here, elements that are seemingly far apart in terms of base pair measurements are quite close to the genetic sequence that is directly responsible for producing a certain protein. Bohnsack et al. (2022) further confirm that when the SARE site is targeted by dCas9-P300 (the promoter histone protein), it enhances the formation of these chromatin loops.

The discovery holds enormous potential in the use of epigenetic tools to reverse SARE site deletion and ultimately increase the effects of alcohol consumption in adolescents. But the road is not so straightforward, the authors note, because these epigenetic tools have diverse functions – other than just modifications at the SARE site – that are not yet fully understood.

The author is a researcher at the Indian Institute of Science (IISc) in Bengaluru and a freelance science communicator. He tweets at @critvik.