According to substance use study, alcohol use disorders account for the majority of substance use disorder cases in the United States, with 14.5 million or 5.3% of Americans age 12 or older meeting the criteria for diagnosed with an alcohol use disorder in 2017 (AUD). It is an important medical and social problem in American society, representing 88,000 deaths per year and more than $250 billion in annual costs. Alcohol abuse is also implicated in cancer, liver disease, and heart disease.
There’s only four drugs approved by the Food and Drug Administration (FDA) for the treatment of AUD: disulfiram, acamprosate, oral naltrexone and injectable naltrexone. One is very old (disulfiram was approved in 1951), most are expensive (injectable naltrexone costs $1,100 to $1,200 per monthly dose), and all have limited to moderate effectiveness, one study found.
Obviously, there is a need for something new, something better, to treat alcoholism. In recent years, at the start psychedelic therapy speculation for alcoholism has turned into progress in discovering how to use psychedelics not only to treat alcoholism, but perhaps even to cure it.
One of the first studies to find out how psilocybin can treat alcoholism dates back to 2015, which was a proof of concept clinical trial which showed promising results.
In 2019, researchers at Johns Hopkins University conducted an anonymous online survey of 343 people (primarily white men) with up to seven years of AUD who said they had completely stopped – or reported a significant reduction – in their alcohol consumption following consumption of psychedelics in non-clinical settings. After the psychedelic experience, 83% no longer met the criteria for alcoholism.
Then there is the pilot test ongoing since February 2021, slated for completion in July, designed to test a strategy for optimizing the set and framework of psilocybin-assisted therapy of alcohol use disorder, initiated because the results suggest that patients with AUD may be less likely to have a mystical experience with standard doses of psilocybin.
Participants in the pilot trial will watch nature-themed video programs during the preparation session and during the ascension phase of the psilocybin experience that the researchers believe will help improve therapy outcomes. psychedelic-assisted without the need for higher doses of psilocybin. He is sponsored by Saint John Cancer Institute in Santa Monica, California.
Another one study by Johns Hopkins University, starting in April 2021, will examine whether a single high oral dose (25 mg) of psilocybin will lead to a reduction in depressive symptoms and alcohol intake compared to placebo in patients with times of major depressive disorder and AUD.
But it’s not just psilocybin. Awakn Life Sciences (OTC: AWKNF)used ketamine for the treatment of alcoholism, goes to his Phase III trial, usually the final step toward FDA approval. The company also works with MDMA for the treatment of alcoholism.
And scientists are returning to examine how LSD can curb alcoholism, or even stop alcoholism, after work in the 1960s was curtailed when LSD was criminalized.
During the 1950s and 1960sthe popularity of psychedelics as a treatment for various ailments soared, with more than 40,000 people receiving LSD between 1950 and 1965.
One such “experimenter” was Alcoholics Anonymous (AA) co-founder Bill Wilson, who promoted the use of LSD to treat alcoholism in the late 1950s and early 1960s. would have believed that LSD, by mimicking insanity, could help alcoholics achieve a central tenet of AA’s twelve-step program. It was about finding “a power greater than ourselves” that “could restore us to sanity”.
Other psychedelics tested for alcoholism include ibogaine. The first controlled clinical trial the study of ibogaine for the treatment of alcoholism is currently underway at the University of Sao Paulo, Brazil.
Researchers are also delving deeper into how ayahuasca can stop alcoholism – with the caveat that it’s not necessarily about the psychedelic used, but about the “fluid and adaptable forms of healing” that play a role. key to successful recovery from addiction with any psychedelic, according to a study. “The sense of being part of a community has significant therapeutic potential,” the study found.